Ok here is my specs
2x dual core 3ghz amd64 fx 74 (running in quad)
2x 8800 756meg xfx gtx
4 gig ocz sli memory
Asus L1N64-SLI WS Quadfather
XFI-Fatality Sound Card
2x WD Raptors 75gig
Samsung 22" 226BW SyncMaster
Vista 64 Ultimate
I found running the retail version of the game all on high settings, runs perfect or so i thought, on 1680 x 1050 all settings on high i get 60+ fps but the problem i was having was when i go to pick up gene bottles for upgrades (apart for the very first one) the game locks up on me and my computer is non-responsive and a hard reboot is required so everytime i play the game now everytime i come across a bottle to pick up i resort to changing 1 optoin in the graphics setting and that is the lighting option above dx10 and it works fine
I know it is a bit of a pain to keep changing it then back again for picking up these gene bottles but for me it is a solution for now till we get a patch...
hope it helps people with similar problems......
good luck



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