-In Bioshock when you first met certain characters(Ryan,Langford,Steinman) you met them by television,unfortunately you were greeted by a still image.In Bioshock 2 when you meet characters by TV,you will be greeted by a fully animated image.
-Tenenbaum now has a new unique model,unlike i Bioshock 1 where it was recycled.
-Sinclair also has a cool unique model and of course we get to meet him face to face.
-Adam slugs can be picked up outside.Collecting a slug gives you +10 ADAM.
-The Gene Bank now has a new internal design.
-Hypnotize now allows you to Hypnotize splicer to protect you for a short amount of time.
-Eleanor is Now confirmed as Lambs Daughter.
-In one of the sequences Lamb tells Delta "That Symbol on your Hand marks you a dead man."
-Apparently Sinclair sold needle-filled toys to children and talks about selling your blood on the Surface.
-Occasionally when using plasmids on the Big sister she will strike you back with the same plasmids with triple the force!