Ok, so you've got the game, you're home ,you've taken it out of the box, you put it in your Xbox360/PC/PS3, you start it up, and this is your first opportunity in the game to do whatever you want.
So what will you do?
Me, I'm gonna get me some money, providing I don't have any already, by beating up some pedestrians. Next I'll "acquire" a car, unless I'm in one already, and drive to the nearest clothes shop. After I pick a nice new outfit, I'm going back to my car to cruise around for a while and see the sights, visit a restaurant and maybe spend about an hour opening and closing the trunk of my car (I've always wanted to be able to open the trunk in a game ^_^)